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Author: c | 2025-04-24

The latest issues of BioWorld, BioWorld MedTech, BioWorld Science and BioWorld Asia Download the latest bioworld update for Android. The new bioworld 0.1 version is now available for free.

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Clinical Arvinas phase III wild card turns over in breast cancerMixed clinical results led shares of Arvinas Inc. (NASDAQ:ARVN) to close March 11 at $8.30, down $9.26, or 52%, after the company and Pfizer Inc. disclosed results from the phase III Veritac-2 study testing vepdegestrant monotherapy vs.... (Bi-)specific gravity: Bambusa, others serious about approachThe recent series A financing by Bambusa Therapeutics Inc. to fund bispecific antibodies for immunological and inflammatory disorders proved investor faith in the new approach with a proven mechanism. Protagonist’s rusfertide hits phase III goals in rare leukemiaRusfertide could become a blockbuster therapy for polycythemia vera, H.C. Wainwright analyst Douglas Tsao wrote March 4 after the injectable hepcidin mimetic peptide hit its primary endpoint and all four key secondary endpoints in the ongoing... ‘Fall’-out hits Irlab shares after phase IIb miss in Parkinson’s The march toward better drugs in Parkinson’s disease suffered a setback as Irlab Therapeutics AB rolled out top-line results from the phase IIb study with pirepemat called React-PD. Vaxcyte phase II PCV valve to open shortly, Pfizer sizers alertAs U.S. regulatory uncertainty swirls around the vaccine space and health care in general, Vaxcyte Inc. stands poised for a readout of phase II infant data by the end of this quarter with VAX-24, the 24-valent pneumococcal conjugate vaccine (PCV).... Lexicon hails Progress in neuropathic pain despite stock sagFor executives of Lexicon Pharmaceuticals Inc., the missed primary endpoint in the phase IIb Progress study testing pilavapadin, its non-opioid candidate, in adults with moderate to severe diabetic peripheral neuropathic pain seemed merely a... More in ClinicalBioWorldThe news source of record covering the development of innovative human therapies for 25+ yearsSubscribeBioWorld MedTechActionable and timely intelligence on advances in medical devices and technologies for 20+ yearsSubscribeBioWorld AsiaA weekly monitor of biopharmaceutical news from the industry’s fastest-growing regionSubscribeBioWorld ScienceEssential discovery and preclinical research news to support crucial drug R&D decisions at the earliest stagesSubscribeBioWorld PremiumEnjoy extended coverage for the most complete market view with BioWorld, BioWorld MedTech, and BioWorld Asia in a single, easy to access subscriptionSubscribe BioWorld - Friday, March 14, 2025Breaking News: Explore BioWorld’s comprehensive infographics collectionBreaking News: Explore BioWorld’s comprehensive infographics collectionBreaking News: BioWorld by Clarivate releases comprehensive 2024 year in review Endo the line: Mallinckrodt merger worth $6.7BThe pairing of Mallinckrodt plc and Endo Inc. is expected to create a pharma heavyweight that will generate $3.6 billion in 2025 revenue after the duo combines their generic pharmaceuticals businesses and Endo’s sterile injectables setup. Terms call for Dublin-based Endo shareholders to collect $80 million in cash and own 49.9% of the combined firm. Owners of stock in Mallinckrodt will hold the rest of the new entity in the arrangement, which bears an enterprise value of $6.7 billion and is expected to close in the second half of this year. US CDC nomination withdrawn, reforms in the works Today's news in brief Endo the line: Mallinckrodt merger worth $6.7BThe pairing of Mallinckrodt plc and Endo Inc. is expected to create a pharma heavyweight that will generate $3.6 billion in 2025 revenue after the duo combines their generic pharmaceuticals businesses and Endo’s sterile injectables setup. Terms call for Dublin-based Endo shareholders to collect $80 million in cash and own 49.9% of the combined firm. Owners of stock in Mallinckrodt will hold the rest of the new entity in the arrangement, which bears an enterprise value of $6.7 billion and is expected to close in the second half of this year. US CDC nomination withdrawn, reforms in the works Shortly before the Senate Health, Education, Labor and Pensions Committee was to hold the first ever confirmation hearing for a U.S. CDC director March 13, it issued a statement saying the hearing was canceled due to the White House withdrawing its nomination of Dave Weldon, a physician and former congressman from Florida. Today's news in briefBioWorld briefs for March 14, 2025. Just one more vote to go for FDA, NIH nomineesAs expected, the U.S. Senate Health, Education, Labor and Pensions Committee voted March 13 to send the nominations of Jay Bhattacharya as NIH director and Martin Makary as FDA commissioner to the Senate floor for confirmation. Bhattacharya received

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New human embryonic models bring hope for insights, but also lots of brouhaha The development of an embryo in its early stages involves a series of processes in which cells interact and organize to form tissues. In humans, these stages are studied with animal models, stem cells and cell aggregates that mimic natural development phases, or with human embryos, depending on their availability and a strict protocol. Now, in back-to-back papers published online in Nature, scientists from Yale University and the University of Cambridge have two new embryonic models formed from human stem cells to study development after embryo implantation in the uterus. Read More B cells get in on the immune checkpoint fray B cells that expressed a constellation of checkpoint inhibitors could be spurred into antitumor activity by deleting or blocking the checkpoint molecule T-cell immunoglobulin and mucin domain 1 (TIM-1). The findings, which were published online in Nature on June 21, 2023, suggest ways to bring B cells into the antitumor fight. More broadly, Lloyd Bod told BioWorld, his laboratory aims to “break the dogma that B cells only produce antibodies.” Read More Visgenx’s VGX-0111 gene therapy shows promise for dry AMD in NHP study Visgenx Inc. has announced promising data from a nonhuman primate (NHP) study of VGX-011... Read More HBV antisense oligonucleotide AHB-137 exerts potent antiviral activity in vivo Recent studies in chronic hepatitis B patients have shown that bepirovirsen, an antisense oligonucleotide (ASO), may be considered a suitable option for the treatment of hepatitis. The latest issues of BioWorld, BioWorld MedTech, BioWorld Science and BioWorld Asia

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A narrow 12-11 party-line vote, but Makary picked up some Democratic support to secure a 14-9 vote. Vivani looking to get slim with Cortigent neurostimulation spinThe Vivani Medical Inc. combination appears to be over less than three years since its inception after the company reported plans to spin off Cortigent, the division that develops brain implants. Vivani said it plans to create two focused companies dedicated to driving current and future value in their respective therapeutic areas. Long COVID science is progressing, though therapies have not yet followedIn 2020, the Conference on Retroviruses and Opportunistic Infections (CROI) was the first scientific conference to move from in-person to virtual due to the COVID-19 pandemic. On the fifth anniversary of the virtual conference, and the pandemic, some of those earliest COVID-19 patients have still not recovered. BioWorld Insider PodcastBillion-dollar biopharma mergers fall short of the dream: Karen Carey, BioWorld’s senior managing editor and chief analyst, crunched the numbers on 21 of the biggest M&As and found very few have been, so far, good deals for the buyer.Listen now Analysis and data insight GSK’s $1.15B Idrx buyout leads slow M&A market as deals stay strong Biopharma deal activity climbed in early 2025, reaching $37.38 billion in the first two months, up from $35.66 billion a year ago. February saw $8.76 billion in deals, down 69% from January’s $28.63 billion, which included 11 transactions valued at $1 billion or more. Early 2025 saw the... Ending ‘pill penalty’ challenges sacred cow status of IRAGetting the Ensuring Pathways to Innovative Cures (EPIC) Act through the U.S. Congress to do away with the “pill penalty” in the Medicare drug price negotiations could require an epic effort, given the current politically fueled atmosphere on the Hill. With the Inflation Reduction Act (IRA), which... Time nigh for I&I? Key data points aheadYesterday’s first part of this two-part series surveyed bispecific antibodies for immunological and inflammatory (I&I) disease. Apart from bispecifics, Leerink analyst Thomas Smith lately has proven interested in I&I overall, unveiling his “five for 2025” in a January report that listed five... More in Analysis and data insight Deals and M&A Gene therapy efforts active, despite low Bluebird, 2seventy bids Ono scoops Ionis' hematology candidate sapablursen for up to $940M Roche, Zealand $5.3B pact focused on amylin analog for obesity Leyden Labs raises $70M, acquires Covbio for intranasal flu drugs The BioWorld Insider podcast: Mega mergers falling short MASH field still hot as Boehringer axes $870M deal with Yuhan Astellas-Yaskawa JV to build robot-based cell production platform Chimerix brings a rare cancer drug to the $935M Jazz party Novartis adds Kyorin’s preclinical MRGPRX2 antagonist in $777M deal Abbvie enters $2.2B deal for Gubra’s amylin obesity drug Financings Visen announces HKD$603M Hong Kong IPOVisen Pharmaceuticals Co. Ltd. announced its initial public offering (IPO) on the Hong Kong Stock exchange (HKEX) to raise roughly HKD$603.3 million (US$77.6 million) to advance its pipeline of endocrinology assets. Keeping a bead on TEAD in mesothelioma, Vivace raises $35M more Valo raises €19M for immunotherapy work February financings slowing, but year outpaces 2022-2023 UK firm Trimtech emerges with $31M seed round for TRIM21 bispecifics More in Financings Science At CROI, HIV cure trials raise hopes for broader applicabilityAt the 2025 meeting of the Conference on Retroviruses and Opportunistic Infections (CROI) it was the best of times, it was the worst of times. On the first full day of the conference, reports from the first HIV cure trial conducted in Africa, the RIO trial and others showed that perhaps, a broadly... CDC briefing: Trump cuts disrupt disease surveillance, deplete talentThree public health experts have voiced concerns that the uncertainties sparked by the Trump administration’s moves to reduce federal spending could limit the U.S. CDC’s ability to track and respond to infectious disease outbreaks and will undermine the public health support system in the U.S. Study looks to noncoding gene variants for new drug targetsA new multi-omics approach to unpicking how noncoding gene variants influence the development of common chronic diseases has identified tens of thousands of instances where variants have an impact on gene expression levels and gene splicing, the post-transcriptional modification that allows one... Synthetic microbiome prevents Clostridioides difficile recurrences Combination therapy overcomes treatment

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twitter4j-media-support-2.2.3.jar241.Download twitter4j-media-support-2.2.4-sources.jar242.Download twitter4j-media-support-2.2.4.jar243.Download twitter4j-media-support-2.2.5-sources.jar244.Download twitter4j-media-support-2.2.5.jar245.Download twitter4j-media-support-2.2.6-sources.jar246.Download twitter4j-media-support-2.2.6.jar247.Download twitter4j-media-support-3.0.0-sources.jar248.Download twitter4j-media-support-3.0.0.jar249.Download twitter4j-media-support-3.0.1-sources.jar250.Download twitter4j-media-support-3.0.1.jar251.Download twitter4j-media-support-3.0.2-sources.jar252.Download twitter4j-media-support-3.0.2.jar253.Download twitter4j-media-support-3.0.3-sources.jar254.Download twitter4j-media-support-3.0.3.jar255.Download twitter4j-media-support-android-2.2.1.jar256.Download twitter4j-media-support-android-2.2.3.jar257.Download twitter4j-media-support-android-2.2.5.jar258.Download twitter4j-stream-2.2.0.jar259.Download twitter4j-stream-2.2.1.jar260.Download twitter4j-stream-2.2.2.jar261.Download twitter4j-stream-2.2.3.jar262.Download twitter4j-stream-2.2.4.jar263.Download twitter4j-stream-2.2.5-sources.jar264.Download twitter4j-stream-2.2.5.jar265.Download twitter4j-stream-2.2.6-sources.jar266.Download twitter4j-stream-2.2.6.jar267.Download twitter4j-stream-3.0.0.jar268.Download twitter4j-stream-3.0.1.jar269.Download twitter4j-stream-3.0.2.jar270.Download twitter4j-stream-3.0.3.jar271.Download twitter4j-stream-android-2.2.1.jar272.Download twitter4j-stream-android-2.2.2.jar273.Download twitter4j-stream-android-2.2.3.jar274.Download twitter4j.jar275.Download twitter4j-1.1.0.jar276.Download twitter4j-1.1.1.jar277.Download twitter4j-1.1.2.jar278.Download twitter4j-1.1.3.jar279.Download twitter4j-1.1.4.jar280.Download twitter4j-1.1.5.jar281.Download twitter4j-1.1.6.jar282.Download twitter4j-1.1.7.jar283.Download twitter4j-1.1.8.jar. 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SearchJar File Downloadttwitter4jDownload twitter4j-examples-3.0.0.jartwitter4j/twitter4j-examples-3.0.0.jar.zip( 111 k)The download jar file contains the following class files or Java source files.META-INF/LICENSE.txtMETA-INF/MANIFEST.MFMETA-INF/maven/org.twitter4j/twitter4j-examples/pom.propertiesMETA-INF/maven/org.twitter4j/twitter4j-examples/pom.xmltwitter4j.examples.account.GetAccountSettings.classtwitter4j.examples.account.GetRateLimitStatus.classtwitter4j.examples.account.UpdateProfile.classtwitter4j.examples.account.UpdateProfileBackgroundImage.classtwitter4j.examples.account.UpdateProfileColors.classtwitter4j.examples.account.UpdateProfileImage.classtwitter4j.examples.account.VerifyCredentials.classtwitter4j.examples.async.AsyncUpdate.classtwitter4j.examples.block.CreateBlock.classtwitter4j.examples.block.DestroyBlock.classtwitter4j.examples.block.GetBlockingUsers.classtwitter4j.examples.block.GetBlockingUsersIDs.classtwitter4j.examples.directmessage.DestroyDirectMessage.classtwitter4j.examples.directmessage.GetDirectMessages.classtwitter4j.examples.directmessage.GetSentDirectMessages.classtwitter4j.examples.directmessage.SendDirectMessage.classtwitter4j.examples.directmessage.ShowDirectMessage.classtwitter4j.examples.favorite.CreateFavorite.classtwitter4j.examples.favorite.DestroyFavorite.classtwitter4j.examples.favorite.GetFavorites.classtwitter4j.examples.friendsandfollowers.GetFollowersIDs.classtwitter4j.examples.friendsandfollowers.GetFriendsIDs.classtwitter4j.examples.friendship.CreateFriendship.classtwitter4j.examples.friendship.DestroyFriendship.classtwitter4j.examples.friendship.GetIncomingFriendships.classtwitter4j.examples.friendship.GetOutgoingFriendships.classtwitter4j.examples.friendship.LookupFriendships.classtwitter4j.examples.friendship.ShowFriendship.classtwitter4j.examples.friendship.UpdateFriendship.classtwitter4j.examples.geo.CreatePlace.classtwitter4j.examples.geo.GetGeoDetails.classtwitter4j.examples.geo.GetSimilarPlaces.classtwitter4j.examples.geo.ReverseGeoCode.classtwitter4j.examples.geo.SearchPlaces.classtwitter4j.examples.help.GetPrivacyPolicy.classtwitter4j.examples.help.GetTermsOfService.classtwitter4j.examples.json.LoadRawJSON.classtwitter4j.examples.json.SaveRawJSON.classtwitter4j.examples.list.AddUserListMember.classtwitter4j.examples.list.AddUserListMembers.classtwitter4j.examples.list.CreateUserList.classtwitter4j.examples.list.CreateUserListSubscription.classtwitter4j.examples.list.DeleteUserListMember.classtwitter4j.examples.list.DestroyUserList.classtwitter4j.examples.list.DestroyUserListSubscription.classtwitter4j.examples.list.GetUserListMembers.classtwitter4j.examples.list.GetUserListMemberships.classtwitter4j.examples.list.GetUserListStatuses.classtwitter4j.examples.list.GetUserListSubscribers.classtwitter4j.examples.list.GetUserListSubscriptions.classtwitter4j.examples.list.GetUserLists.classtwitter4j.examples.list.ShowUserList.classtwitter4j.examples.list.ShowUserListMembership.classtwitter4j.examples.list.ShowUserListSubscription.classtwitter4j.examples.list.UpdateUserList.classtwitter4j.examples.media.ImgLyImageUpload.classtwitter4j.examples.media.PlixiImageUpload.classtwitter4j.examples.media.TwippleImageUpload.classtwitter4j.examples.media.TwitgooImageUpload.classtwitter4j.examples.media.TwitpicImageUpload.classtwitter4j.examples.media.YFrogImageUpload.classtwitter4j.examples.oauth.GetAccessToken.classtwitter4j.examples.savedsearches.CreateSavedSearch.classtwitter4j.examples.savedsearches.DestroySavedSearch.classtwitter4j.examples.savedsearches.GetSavedSearches.classtwitter4j.examples.savedsearches.ShowSavedSearch.classtwitter4j.examples.search.SearchTweets.classtwitter4j.examples.spamreporting.ReportSpam.classtwitter4j.examples.stream.PrintFilterStream.classtwitter4j.examples.stream.PrintFirehoseStream.classtwitter4j.examples.stream.PrintLinksStream.classtwitter4j.examples.stream.PrintRetweetStream.classtwitter4j.examples.stream.PrintSampleStream.classtwitter4j.examples.stream.PrintSiteStreams.classtwitter4j.examples.stream.PrintUserStream.classtwitter4j.examples.suggestedusers.GetMemberSuggestions.classtwitter4j.examples.suggestedusers.GetSuggestedUserCategories.classtwitter4j.examples.suggestedusers.GetUserSuggestions.classtwitter4j.examples.timeline.GetHomeTimeline.classtwitter4j.examples.timeline.GetMentions.classtwitter4j.examples.timeline.GetUserTimeline.classtwitter4j.examples.trends.GetAvailableTrends.classtwitter4j.examples.tweets.DestroyStatus.classtwitter4j.examples.tweets.GetRetweets.classtwitter4j.examples.tweets.RetweetStatus.classtwitter4j.examples.tweets.ShowStatus.classtwitter4j.examples.tweets.UpdateStatus.classtwitter4j.examples.user.LookupUsers.classtwitter4j.examples.user.SearchUsers.classtwitter4j.examples.user.ShowUser.classRelated examples in the same category1.Download twitter4j-0.3-sources.jar2.Download twitter4j-0.3.jar3.Download twitter4j-2.0.0.jar4.Download twitter4j-2.0.1-sources.jar5.Download twitter4j-1.0.3.jar6.Download twitter4j-1.0.4.jar7.Download twitter4j-1.0.5.jar8.Download twitter4j-1.0.6.jar9.Download twitter4j-async-2.2.2-sources.jar10.Download twitter4j-examples-2.2.2-sources.jar11.Download twitter4j-httpclient-support-2.1.9-sources.jar12.Download twitter4j-media-support-2.1.10-sources.jar13.Download twitter4j-media-support-2.1.10.jar14.Download twitter4j-media-support-2.1.11.jar15.Download twitter4j-media-support-3.0.4-sources.jar16.Download twitter4j-media-support-3.0.4.jar17.Download twitter4j-appengine-3.0.3-sources.jar18.Download twitter4j-appengine-3.0.4-sources.jar19.Download twitter4j-appengine-3.0.4.jar20.Download twitter4j-async-2.2.0-sources.jar21.Download twitter4j-async-2.2.3-sources.jar22.Download twitter4j-async-2.2.4-sources.jar23.Download twitter4j-async-3.0.0-sources.jar24.Download twitter4j-async-3.0.0.jar25.Download twitter4j-async-3.0.1-sources.jar26.Download twitter4j-async-3.0.1.jar27.Download twitter4j-async-3.0.2-sources.jar28.Download twitter4j-async-3.0.3-sources.jar29.Download twitter4j-async-3.0.4-sources.jar30.Download twitter4j-async-3.0.4.jar31.Download twitter4j-core-2.1.0-sources.jar32.Download twitter4j-core-2.1.0.jar33.Download twitter4j-core-2.1.1-sources.jar34.Download twitter4j-core-2.1.1.jar35.Download twitter4j-core-2.1.10-sources.jar36.Download twitter4j-core-2.1.10.jar37.Download twitter4j-core-2.1.11-sources.jar38.Download twitter4j-core-2.1.11.jar39.Download twitter4j-core-2.1.12-sources.jar40.Download twitter4j-core-2.1.12.jar41.Download twitter4j-core-2.1.2-sources.jar42.Download twitter4j-core-2.1.2.jar43.Download twitter4j-core-2.1.3-sources.jar44.Download twitter4j-core-2.1.3.jar45.Download twitter4j-core-2.1.4-sources.jar46.Download twitter4j-core-2.1.4.jar47.Download twitter4j-core-2.1.5-sources.jar48.Download twitter4j-core-2.1.5.jar49.Download twitter4j-core-2.1.6-sources.jar50.Download twitter4j-core-2.1.6.jar51.Download twitter4j-core-2.1.7-sources.jar52.Download twitter4j-core-2.1.7.jar53.Download twitter4j-core-2.1.8-sources.jar54.Download twitter4j-core-2.1.8.jar55.Download twitter4j-core-2.1.9-sources.jar56.Download twitter4j-core-2.1.9.jar57.Download twitter4j-core-2.2.3-sources.jar58.Download twitter4j-core-2.2.4-sources.jar59.Download twitter4j-core-3.0.4-sources.jar60.Download twitter4j-core-3.0.4.jar61.Download twitter4j-examples-2.1.1-sources.jar62.Download twitter4j-examples-2.1.1.jar63.Download twitter4j-examples-2.1.10-sources.jar64.Download twitter4j-examples-2.1.10.jar65.Download twitter4j-examples-2.1.11-sources.jar66.Download twitter4j-examples-2.1.11.jar67.Download twitter4j-examples-2.1.12-sources.jar68.Download twitter4j-examples-2.1.12.jar69.Download twitter4j-examples-2.1.2-sources.jar70.Download twitter4j-examples-2.1.2.jar71.Download twitter4j-examples-2.1.3-sources.jar72.Download twitter4j-examples-2.1.4-sources.jar73.Download twitter4j-examples-2.1.5-sources.jar74.Download twitter4j-examples-2.1.6-sources.jar75.Download twitter4j-examples-2.1.7-sources.jar76.Download twitter4j-examples-2.1.8-sources.jar77.Download twitter4j-examples-2.1.9-sources.jar78.Download twitter4j-examples-2.2.0-sources.jar79.Download twitter4j-examples-2.2.1-sources.jar80.Download twitter4j-examples-2.2.3-sources.jar81.Download twitter4j-examples-2.2.4-sources.jar82.Download twitter4j-examples-3.0.0-sources.jar83.Download twitter4j-examples-3.0.1-sources.jar84.Download twitter4j-examples-3.0.2-sources.jar85.Download twitter4j-examples-3.0.3-sources.jar86.Download twitter4j-examples-3.0.4-sources.jar87.Download twitter4j-examples-3.0.4.jar88.Download twitter4j-httpclient-support-2.1.10-sources.jar89.Download twitter4j-httpclient-support-2.1.10.jar90.Download 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